Facultad de Medicina y Ciencias de la Salud Universidad Abierta Interamericana
Facultad de Medicina y Ciencias de la Salud Universidad Abierta Interamericana
Background: Translational studies and translational research refer to a process that aims to take discoveries from basic sciences to develop effective actions for the benefit of the population. These studies have different stages and in this systematic review I will focus on the valley of death or translational gap ("translational bridge") of vaccine prospects lost in this statistical space, having as a timeframe the beginning of the Covid19 pandemic, until the approval of the first vaccine. Material and methods: I will use the clinicaltrials.gov search engine to track studies from phase 1, considering that the common starting point for all studies is the discovery of a new coronavirus until phase 4. Results: Phase I the average of the JADAD Scale obtained is 3.6, Phase II 3.1 on average and Phase III 3.3. Conclusion: In these studies, other scales are used to measure methodological quality, since their inability to significantly predict the progression of vaccine leaflet studies suggests that other factors may be influencing decision making to advance to subsequent clinical phases
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.