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Association between levodopa administration and melanoma: A systematic review

By
Fernanda Luparelli Mello ,
Fernanda Luparelli Mello

Facultad de Medicina y Ciencias de la Salud - Universidad Abierta Interamericana

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Marcelo Adrian Estrin ,
Marcelo Adrian Estrin

Facultad de Medicina y Ciencias de la Salud - Universidad Abierta Interamericana

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Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disease and levodopa is the main drug used in the treatment of this disease. A study conducted in Denmark demonstrated a two-fold higher incidence of malignant melanoma in patients with Parkinson's, but no correlation was found between levodopa treatment and this incidence. Material and methods: The present systematic review used search engines such as pubmed and Google academic to search for articles of the clinical and randomized trial type. Results: The results of the systematic review indicate a complexity in the relationship between levodopa administration, Parkinson's disease, and melanoma risk. The evidence reviewed suggests that levodopa does not appear to be a significant causal factor in the development of melanoma in patients with Parkinson's disease. Despite the problems raised, the well-established therapeutic benefits of levodopa in the management of the symptoms of Parkinson's disease continue to outweigh the potential risk of causing melanoma. Conclusion: The study concludes that there is an increased risk of developing melanoma in patients with Parkinson's disease but that there is no evidence of a causal role of levodopa in increasing this risk or accelerating its growth

How to Cite

1.
Luparelli Mello F, Estrin MA. Association between levodopa administration and melanoma: A systematic review . SCT Proceedings in Interdisciplinary Insights and Innovations [Internet]. 2024 Jun. 12 [cited 2024 Jul. 18];2:355. Available from: https://proceedings.saludcyt.ar/index.php/piii/article/view/355

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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